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Experimental gene therapy successfully revives immune systems in children with deadly disorder |

A new experimental gene therapy has successfully restored immune system function in children born with ADA-SCID, a rare and potentially fatal genetic immune disorder. Developed by researchers at UCLA, University College London, and Great Ormond Street Hospital, the therapy treated 59 out of 62 children. ADA-SCID is caused by mutations in the ADA gene, which…

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Nobel Prize 2025: Three scientists share Physiology or Medicine award; honored for discoveries on peripheral immune tolerance

The 2025 Nobel Prize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi for their groundbreaking discoveries on peripheral immune tolerance, a mechanism that prevents the body’s immune system from attacking its own cells.Announced on Monday by Sweden’s Karolinska Institute, the award recognises decades of research that deepened…

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